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2015 ; 59
(sup1
): 59-63
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Using C elegans for aging research
#MMPMID26136622
Tissenbaum HA
Invertebr Reprod Dev
2015[Jan]; 59
(sup1
): 59-63
PMID26136622
show ga
Over a century ago, the zoologist Emile Maupas first identified the nematode,
Rhabditis elegans, in the soil in Algiers. Subsequent work and phylogenic studies
renamed the species Caenorhabditis elegans or more commonly referred to as C.
elegans; (Caeno meaning recent; rhabditis meaning rod; elegans meaning nice).
However, it was not until 1963, when Sydney Brenner, already successful from his
work on DNA, RNA, and the genetic code, suggested the future of biological
research lay in model organisms. Brenner believed that biological research
required a model system that could grow in vast quantities in the lab, were cheap
to maintain and had a simple body plan, and he chose the nematode C. elegans to
fulfill such a role. Since that time, C. elegans has emerged as one of the
premiere model systems for aging research. This paper reviews some initial
identification of mutants with altered lifespan with a focus on genetics and then
discusses advantages and disadvantages for using C. elegans as a model system to
understand human aging. This review focuses on molecular genetics aspects of this
model organism.
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