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Microbiol Spectr
2016[Jun]; 4
(3
): ? PMID27337488
show ga
Escherichia coli are a common cause of infectious disease outside of the
gastrointestinal tract. Several independently evolved E. coli clades are common
causes of urinary tract and bloodstream infections. There is ample
epidemiological and in vitro evidence that several different protein toxins
common to many, but not all, of these strains are likely to aid the colonization
and immune-evasion ability of these bacteria. This review discusses our current
knowledge and areas of ignorance concerning the contribution of the hemolysin;
cytotoxic-necrotizing factor-1; and the autotransporters, Sat, Pic, and Vat, to
extraintestinal human disease.
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