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2018 ; 9
(1
): 189
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Urine-derived cells for human cell therapy
#MMPMID29996911
Pavathuparambil Abdul Manaph N
; Al-Hawwas M
; Bobrovskaya L
; Coates PT
; Zhou XF
Stem Cell Res Ther
2018[Jul]; 9
(1
): 189
PMID29996911
show ga
Desirable cells for human cell therapy would be ones that can be generated by
simple isolation and culture techniques using a donor sample obtained by
non-invasive methods. To date, the different donor-specific cells that can be
isolated from blood, skin, and hair require invasive methods for sample isolation
and incorporate complex and costly reagents to culture. These cells also take
considerable time for their in-vitro isolation and expansion. Previous studies
suggest that donor-derived cells, namely urine stem cells and renal cells, may be
isolated from human urine samples using a cost-effective and simple method of
isolation, incorporating not such complex reagents. Moreover, the isolated cells,
particularly urine stem cells, are superior to conventional stem cell sources in
terms of favourable gene profile and inherent multipotent potential.
Transdifferentiation or differentiation of human urine-derived cells can generate
desirable cells for regenerative therapy. In this review, we intended to discuss
the characteristics and therapeutic applications of urine-derived cells for human
cell therapy. Conclusively, with detailed study and optimisation, urine-derived
cells have a prospective future to generate functional lineage-specific cells for
patients from a clinical translation point of view.