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1990 ; 5
(1
): 58-62
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Urinary plasminogen activator activity in progressive renal failure
#MMPMID2271512
Hong SY
; Yang DH
Korean J Intern Med
1990[Jan]; 5
(1
): 58-62
PMID2271512
show ga
The purpose of this study was to discover how functional nephrons produce the
plasminogen activator as renal function progresses to renal failure. Urine
Plasminogen activator (U-PA) activity was measured by the fibrin plate method in
73 patients with various degrees of renal function deterioration from various
underlying diseases and in one healthy individual in order to evaluate the
plasminogen activator activity of remnant nephrons. The plasminogen activator
activity of the 12 consecutive urine samples from the healthy individual showed
that is varied according to the time of day, but there was no circadian rhythm.
The urine plasminogen activator activity correlated with the osmolality (r =
0.51, P less than 0.001) and creatinine (r = 0.56, P less than 0.001) of the
urine, suggesting that it is concentrated at distal nephrons. The fractional
sodium excretion rate (FeNa) increased abruptly when GFR decreased below 25
L/day. This pattern was very similar with the relation between total U-PA
activity/GFR and GFR. The correlation between total U-PA activity and FeNa was
not significant, but there was a significant direct correlation between total
U-PA activity/GFR and FeNa (r = 0.775, P less than 0.0001). There was no
relationship between the 24-hour urine protein and total U-PA activity or total
U-PA activity/GFR.(ABSTRACT TRUNCATED AT 250 WORDS)