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2013 ; 177
(11
): 1263-70
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Urinary bisphenol A and obesity in U S children
#MMPMID23558351
Bhandari R
; Xiao J
; Shankar A
Am J Epidemiol
2013[Jun]; 177
(11
): 1263-70
PMID23558351
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Childhood obesity, a major public health problem, can lead to cardiovascular
disease in adulthood. Studies have implicated exposure to bisphenol A (BPA), a
commonly used chemical, in the development of obesity in adults. However,
literature is limited on this association in children. We examined the
association between urinary BPA and obesity in children aged 6-18 years from the
National Health and Nutrition Examination Survey (2003-2008). The primary
exposure was urinary BPA and the outcome was obesity, defined as the ? 95th
percentile of body mass index specific for age and sex. We found a positive
association between increasing levels of urinary BPA and obesity, independent of
age, sex, race/ethnicity, education, physical activity, serum cotinine, and
urinary creatinine. Compared with children in the lowest quartile of BPA (<1.5
ng/mL), children in the highest quartile (>5.4 ng/mL) had a multivariable odds
ratio for obesity of 2.55 (95% confidence interval (CI): 1.65, 3.95) (Ptrend <
0.01). The observed positive association was predominantly present in boys (odds
ratio = 3.80, 95% CI: 2.25, 6.43) (Ptrend < 0.001) and in non-Hispanic whites
(odds ratio = 5.87, 95% CI: 2.15, 16.05) (Ptrend < 0.01). In a representative
sample of children, urinary BPA was associated with obesity, predominantly in
non-Hispanic white boys, independent of major risk factors.
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