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2018 ; 5
(ä): 72
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Urinary Virome Perturbations in Kidney Transplantation
#MMPMID29725592
Sigdel TK
; Mercer N
; Nandoe S
; Nicora CD
; Burnum-Johnson K
; Qian WJ
; Sarwal MM
Front Med (Lausanne)
2018[]; 5
(ä): 72
PMID29725592
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The human microbiome is important for health and plays a role in essential
metabolic functions and protection from certain pathogens. Conversely, dysbiosis
of the microbiome is seen in the context of various diseases. Recent studies have
highlighted that a complex microbial community containing hundreds of bacteria
colonizes the healthy urinary tract, but little is known about the human urinary
viruses in health and disease. To evaluate the human urinary virome in the
context of kidney transplantation (tx), variations in the composition of the
urinary virome were evaluated in urine samples from normal healthy volunteers as
well as patients with kidney disease after they had undergone kidney tx. Liquid
chromatography-mass spectrometry/mass spectrometry analysis was undertaken on a
selected cohort of 142 kidney tx patients and normal healthy controls, from a
larger biobank of 770 kidney biopsy matched urine samples. In addition to
analysis of normal healthy control urine, the cohort of kidney tx patients had
biopsy confirmed phenotype classification, coincident with the urine sample
analyzed, of stable grafts (STA), acute rejection, BK virus nephritis, and
chronic allograft nephropathy. We identified 37 unique viruses, 29 of which are
being identified for the first time in human urine samples. The composition of
the human urinary virome differs in health and kidney injury, and the
distribution of viral proteins in the urinary tract may be further impacted by IS
exposure, diet and environmental, dietary, or cutaneous exposure to various
insecticides and pesticides.
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