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2018 ; 2018
(ä): 8658507
Nephropedia Template TP
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Urinary Clusterin Is Upregulated in Nephropathia Epidemica
#MMPMID29682100
Martynova EV
; Maksudova AN
; Shakirova VG
; Abdulkhakov SR
; Khaertynova IM
; Anokhin VA
; Ivanova VV
; Abiola IM
; Garanina EE
; Tazetdinova LG
; Valiullina AH
; Khaiboullina SF
Dis Markers
2018[]; 2018
(ä): 8658507
PMID29682100
show ga
Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is
known about the mechanisms of the NE kidney pathology, with current knowledge
mainly based on findings in postmortem tissue. We have analyzed kidney damage
biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney
toxicity panels 1 and 2. To determine the disease specificity, kidney damage
biomarkers were also analyzed in urine samples from patients diagnosed with gout,
type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency.
Analysis of 12 biomarkers suggests damage to the kidney proximal tubule at the
onset of NE. Also, upregulation of biomarkers of inflammation and leukocyte
chemotaxis were detected in NE urine. Furthermore, increased clusterin levels
were found in early- and late-phase NE urine. Comparative analysis revealed that
clusterin is a biomarker, upregulated in NE urine.
|Biomarkers/urine
[MESH]
|Clusterin/*urine
[MESH]
|Female
[MESH]
|Hemorrhagic Fever with Renal Syndrome/*urine
[MESH]