Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29723981
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Toxics
2018 ; 6
(2
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Urinary Cadmium Threshold to Prevent Kidney Disease Development
#MMPMID29723981
Satarug S
; Ruangyuttikarn W
; Nishijo M
; Ruiz P
Toxics
2018[May]; 6
(2
): ä PMID29723981
show ga
The frequently observed association between kidney toxicity and long-term cadmium
(Cd) exposure has long been dismissed and deemed not to be of clinical relevance.
However, Cd exposure has now been associated with increased risk of developing
chronic kidney disease (CKD). We investigated the link that may exist between
kidney Cd toxicity markers and clinical kidney function measure such as estimated
glomerular filtration rates (eGFR). We analyzed data from 193 men to 202 women,
aged 16−87 years [mean age 48.8 years], who lived in a low- and high-Cd
exposure areas in Thailand. The mean (range) urinary Cd level was 5.93 (0.05?57)
μg/g creatinine. The mean (range) for estimated GFR was 86.9
(19.6−137.8) mL/min/1.73 m². Kidney pathology reflected by urinary
β2-microglobulin (β2-MG) levels ≥ 300 μg/g creatinine showed an
association with 5.32-fold increase in prevalence odds of CKD (p = 0.001), while
urinary Cd levels showed an association with a 2.98-fold greater odds of CKD
prevalence (p = 0.037). In non-smoking women, Cd in the highest urinary Cd
quartile was associated with 18.3 mL/min/1.73 m² lower eGFR value, compared to
the lowest quartile (p < 0.001). Evidence for Cd-induced kidney pathology could
thus be linked to GFR reduction, and CKD development in Cd-exposed people. These
findings may help prioritize efforts to reassess Cd exposure and its impact on
population health, given the rising prevalence of CKD globally.