Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27600582
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Rev+Endocr+Metab+Disord
2017 ; 18
(1
): 41-47
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Updates in hyperkalemia: Outcomes and therapeutic strategies
#MMPMID27600582
Kovesdy CP
Rev Endocr Metab Disord
2017[Mar]; 18
(1
): 41-47
PMID27600582
show ga
Hyperkalemia is a frequent clinical abnormality in patients with chronic kidney
disease, and it is associated with higher risk of mortality and malignant
arrhythmias. Severe hyperkalemia is a medical emergency, which requires immediate
therapies, followed by interventions aimed at preventing its recurrence. Current
treatment paradigms for chronic hyperkalemia management are focused on
eliminating predisposing factors, such as high potassium intake in diets or
supplements, and the use of medications known to raise potassium level. Among the
latter, inhibitors of the renin-angiotensin aldosterone system are some of the
most commonly involved medications, and their discontinuation is often the first
step taken by clinicians to prevent the recurrence of hyperkalemia. While this
strategy is usually successful, it also deprives patients of the recognized
benefits of this class, such as their renoprotective effects. The development of
novel potassium binders has ushered in a new era of hyperkalemia management, with
a focus on chronic therapy while maintaining the use of beneficial, but
hyperkalemia-inducing medications such as renin-angiotensin aldosterone system
inhibitors. This review article examines the incidence and clinical consequences
of hyperkalemia, and its various treatment options, with special emphasis on
novel therapeutic agents and the potential benefits of their application.