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2017 ; 5
(ä): 47
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Update on pediatric sepsis: a review
#MMPMID28729906
Kawasaki T
J Intensive Care
2017[]; 5
(ä): 47
PMID28729906
show ga
BACKGROUND: Sepsis is one of the leading causes of mortality among children
worldwide. Unfortunately, however, reliable evidence was insufficient in
pediatric sepsis and many aspects in clinical practice actually depend on expert
consensus and some evidence in adult sepsis. More recent findings have given us
deep insights into pediatric sepsis since the publication of the Surviving Sepsis
Campaign guidelines 2012. MAIN TEXT: New knowledge was added regarding the
hemodynamic management and the timely use of antimicrobials. Quality improvement
initiatives of pediatric "sepsis bundles" were reported to be successful in
clinical outcomes by several centers. Moreover, a recently published global
epidemiologic study (the SPROUT study) did not only reveal the demographics,
therapeutic interventions, and prognostic outcomes but also elucidated the
inappropriateness of the current definition of pediatric sepsis. CONCLUSIONS:
With these updated knowledge, the management of pediatric sepsis would be
expected to make further progress. In addition, it is meaningful that the
fundamental data on which future research should be based were established
through the SPROUT study.