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2020 ; 257
(ä): 118063
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Update on neurological manifestations of COVID-19
#MMPMID32652139
Yavarpour-Bali H
; Ghasemi-Kasman M
Life Sci
2020[Sep]; 257
(ä): 118063
PMID32652139
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Novel coronavirus (severe acute respiratory syndrome coronavirus-2: SARS-CoV-2)
has a high homology with other cousin of coronaviruses such as SARS and Middle
East respiratory syndrome-related coronavirus (MERS). After outbreak of the
SARS-CoV-2 in China, it has spread so fast around the world. The main
complication of coronavirus disease 2019 (COVID-19) is respiratory failure, but
several patients have also been admitted to the hospital with neurological
symptoms. Direct invasion, hematogenic rout, retrograde and anterograde transport
along peripheral nerves are considered as main neuroinvasion mechanisms of
SARS-CoV-2. In the present study, we describe the possible routes for entering of
SARS-CoV-2 into the nervous system. Then, the neurological manifestations of the
SARS-CoV-2 infection in the central nervous system (CNS) and peripheral nervous
system (PNS) are reviewed. Furthermore, the neuropathology of the virus and its
impacts on other neurological disorders are discussed.
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