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2016 ; 28
(5
): 468-76
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Update on cardiovascular disease in lupus
#MMPMID27227346
Lewandowski LB
; Kaplan MJ
Curr Opin Rheumatol
2016[Sep]; 28
(5
): 468-76
PMID27227346
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PURPOSE OF REVIEW: Atherosclerotic cardiovascular disease confers significant
morbidity and mortality in patients with systemic lupus erythematosus (SLE) and
cannot be fully explained by traditional cardiovascular risk factors. Recent
immunologic discoveries have outlined putative pathways in SLE that may also
accelerate the development of atherosclerosis. RECENT FINDINGS: Aberrant innate
and adaptive immune responses implicated in lupus pathogenesis may also
contribute to the development of accelerated atherosclerosis in these patients.
Defective apoptosis, abnormal lipoprotein function, autoantibodies, aberrant
neutrophil responses, and a dysregulated type I interferon pathway likely
contribute to endothelial dysfunction. SLE macrophages have an inflammatory
phenotype that may drive progression of plaque. SUMMARY: Recent discoveries have
placed increased emphasis on the immunology of atherosclerotic cardiovascular
disease. Understanding the factors that drive the increased risk for
cardiovascular disease in SLE patients may provide selective therapeutic targets
for reducing inflammation and improving outcomes in atherosclerosis.
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