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2015 ; 32
(6
): 566-71
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Unusual lesions of the mediastinum
#MMPMID26664161
Shamsuddin F
; Khadilkar UN
; Saha D
Lung India
2015[Nov]; 32
(6
): 566-71
PMID26664161
show ga
OBJECTIVES: To study unusual lesions in the mediastinum, which do not originate
from the thymus, lymph nodes, neural tissues or germ cells, and tissues that
normally engender pathologic lesions in the mediastinum. MATERIALS AND METHODS:
Of the 65 cases seen, 12 unusual lesion were encountered in a 5½ year period from
2006 to 2011. RESULTS: Two cases of nodular colloid goiter and one each of the
mediastinal cyst, undifferentiated carcinoma, and Langerhans cell histiocytosis
(LCH) affected the anterosuperior mediastinum. In the middle mediastinum, one
case each of the mesothelioma, malignant gastrointestinal stromal tumor (GIST),
squamous cell carcinoma (SCC), solitary fibrous tumor (SFT), and pleomorphic
sarcoma (PS) was seen. One case of meningeal melanocytoma (Mme) and primary
pleural liposarcoma (PL) involved the posterior mediastinum. Persistent disease
was seen in LCH after 2 years. Of all the cases with malignant lesions, only the
patient with SCC was alive after 1 year. CONCLUSION: The cases of primary and
SCC, LCH, melanocytoma, liposarcoma and PS, and GIST are unexpected and very
rarely have paradigms in the mediastinum. Radiologic impression and knowledge of
the compartment where these lesions arose from hardly assisted in arriving at a
definitive opinion as the lesions were not typical of this location. A high index
of suspicion and the immunohistochemical profile facilitated the final diagnosis.
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