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10.1159/000430881 http://scihub22266oqcxt.onion/10.1159/000430881 C4668799!4668799 !26675070     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26675070 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Gastrointest+Tumors 2015 ; 2 (2 ): 83-8 Nephropedia Template TP {{tp|p=26675070 |t=2015. Unusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma |pdf=|usr=}}{{26675070 }} gab.com Text Unusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma JO: Gastrointest Tumors http://www.kidney.de/pget.php?&tw=1&pmid=26675070 #FOAvip BACKGROUND: Use of molecular assays is gradually becoming a mandatory part of the clinical management of soft tissue tumors, however the choice and the interpretation of these tests may present a challenge. SUMMARY: This report demonstrates an unusual presentation of sarcoma, which was initially diagnosed as a tumor of unknown primary site. Given the presence of vimentin, Fli-1, CD99 and S100 markers, lack of immunostaining for melan A, HMB45, MITF, synaptophysin, CD56, myf4, CKAE1/3 and WT-1, as well as the presence of EWSR1 translocation determined by a break-apart FISH assay, Ewing's sarcoma (ES) diagnosis seemed to be well justified. However, polymerase chain reaction testing for ES-specific rearrangements (EWSR1/FLI1, EWSR1/ERG, EWSR1/ETV1, EWSR1/ETV4, EWS/FEV) failed to confirm the ES origin of the neoplastic tissue. We further considered clinical, morphological, immunohistochemical and molecular diagnostic features of other types of EWSR1-rearranged sarcomas and performed molecular testing for gastrointestinal clear cell sarcoma. The polymerase chain reaction assay revealed EWSR1ex7/ATF1ex5 fusion, thus confirming the latter diagnosis. Subsequent high-precision computed tomography of the abdominal cavity revealed a 5-cm tumor of the small bowel, which was subjected to surgical resection. KEY MESSAGE: This report exemplifies that the use of anonymous cytogenetic assays, such as break-apart FISH EWSR1 testing, may not be sufficient even in case of a perfect match with relevant morphological and immunohistochemical tumor features. PRACTICAL IMPLICATIONS: Explicit identification of the translocation gene partners is indeed important for proper sarcoma diagnosis management. Twit Text FOAVip Unusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma ????Gastrointest Tumors http://www.kidney.de/pget.php?&tw=1&pmid=26675070 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26675070 #FOAvip English Wikipedia <ref>{{Cite pmid|26675070 }}</ref> Unusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma #MMPMID26675070 Raskin GA ; Pozharisski KM ; Iyevleva AG ; Rikov IV ; Orlova RV ; Imyanitov EN Gastrointest Tumors 2015[Sep]; 2 (2 ): 83-8 PMID26675070 show ga BACKGROUND: Use of molecular assays is gradually becoming a mandatory part of the clinical management of soft tissue tumors, however the choice and the interpretation of these tests may present a challenge. SUMMARY: This report demonstrates an unusual presentation of sarcoma, which was initially diagnosed as a tumor of unknown primary site. Given the presence of vimentin, Fli-1, CD99 and S100 markers, lack of immunostaining for melan A, HMB45, MITF, synaptophysin, CD56, myf4, CKAE1/3 and WT-1, as well as the presence of EWSR1 translocation determined by a break-apart FISH assay, Ewing's sarcoma (ES) diagnosis seemed to be well justified. However, polymerase chain reaction testing for ES-specific rearrangements (EWSR1/FLI1, EWSR1/ERG, EWSR1/ETV1, EWSR1/ETV4, EWS/FEV) failed to confirm the ES origin of the neoplastic tissue. We further considered clinical, morphological, immunohistochemical and molecular diagnostic features of other types of EWSR1-rearranged sarcomas and performed molecular testing for gastrointestinal clear cell sarcoma. The polymerase chain reaction assay revealed EWSR1ex7/ATF1ex5 fusion, thus confirming the latter diagnosis. Subsequent high-precision computed tomography of the abdominal cavity revealed a 5-cm tumor of the small bowel, which was subjected to surgical resection. KEY MESSAGE: This report exemplifies that the use of anonymous cytogenetic assays, such as break-apart FISH EWSR1 testing, may not be sufficient even in case of a perfect match with relevant morphological and immunohistochemical tumor features. PRACTICAL IMPLICATIONS: Explicit identification of the translocation gene partners is indeed important for proper sarcoma diagnosis management. äUnusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma (epmc).pdf DeepDyve Pubget Overpricing