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10.1534/genetics.114.170472 http://scihub22266oqcxt.onion/10.1534/genetics.114.170472 C4224152!4224152 !25217049     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25217049 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25217049 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genetics 2014 ; 198 (3 ): 1059-69 Nephropedia Template TP {{tp|p=25217049 |t=2014. Unisexual reproduction reverses Muller s ratchet |pdf=|usr=}}{{25217049 }} gab.com Text Unisexual reproduction reverses Muller s ratchet JO: Genetics http://www.kidney.de/pget.php?&tw=1&pmid=25217049 #FOAvip Cryptococcus neoformans is a pathogenic basidiomycetous fungus that engages in outcrossing, inbreeding, and selfing forms of unisexual reproduction as well as canonical sexual reproduction between opposite mating types. Long thought to be clonal, >99% of sampled environmental and clinical isolates of C. neoformans are MAT?, limiting the frequency of opposite mating-type sexual reproduction. Sexual reproduction allows eukaryotic organisms to exchange genetic information and shuffle their genomes to avoid the irreversible accumulation of deleterious changes that occur in asexual populations, known as Muller's ratchet. We tested whether unisexual reproduction, which dispenses with the requirement for an opposite mating-type partner, is able to purge the genome of deleterious mutations. We report that the unisexual cycle can restore mutant strains of C. neoformans to wild-type genotype and phenotype, including prototrophy and growth rate. Furthermore, the unisexual cycle allows attenuated strains to purge deleterious mutations and produce progeny that are returned to wild-type virulence. Our results show that unisexual populations of C. neoformans are able to avoid Muller's ratchet and loss of fitness through a unisexual reproduction cycle involving ?-? cell fusion, nuclear fusion, and meiosis. Similar types of unisexual reproduction may operate in other pathogenic and saprobic eukaryotic taxa. Twit Text FOAVip Unisexual reproduction reverses Muller s ratchet ????Genetics http://www.kidney.de/pget.php?&tw=1&pmid=25217049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25217049 #FOAvip English Wikipedia <ref>{{Cite pmid|25217049 }}</ref> Unisexual reproduction reverses Muller s ratchet #MMPMID25217049 Roach KC ; Heitman J Genetics 2014[Nov]; 198 (3 ): 1059-69 PMID25217049 show ga Cryptococcus neoformans is a pathogenic basidiomycetous fungus that engages in outcrossing, inbreeding, and selfing forms of unisexual reproduction as well as canonical sexual reproduction between opposite mating types. Long thought to be clonal, >99% of sampled environmental and clinical isolates of C. neoformans are MAT?, limiting the frequency of opposite mating-type sexual reproduction. Sexual reproduction allows eukaryotic organisms to exchange genetic information and shuffle their genomes to avoid the irreversible accumulation of deleterious changes that occur in asexual populations, known as Muller's ratchet. We tested whether unisexual reproduction, which dispenses with the requirement for an opposite mating-type partner, is able to purge the genome of deleterious mutations. We report that the unisexual cycle can restore mutant strains of C. neoformans to wild-type genotype and phenotype, including prototrophy and growth rate. Furthermore, the unisexual cycle allows attenuated strains to purge deleterious mutations and produce progeny that are returned to wild-type virulence. Our results show that unisexual populations of C. neoformans are able to avoid Muller's ratchet and loss of fitness through a unisexual reproduction cycle involving ?-? cell fusion, nuclear fusion, and meiosis. Similar types of unisexual reproduction may operate in other pathogenic and saprobic eukaryotic taxa. |Animals [MESH] |Cryptococcosis/microbiology [MESH] |Cryptococcus neoformans/cytology/*genetics/growth & development/pathogenicity [MESH] |Disease Models, Animal [MESH] |Genetic Fitness [MESH] |Genetic Loci [MESH] |Mice [MESH] |Mutation/*genetics [MESH] |Reproduction, Asexual/*genetics [MESH]Unisexual reproduction reverses Muller s ratchet (epmc).pdf DeepDyve Pubget Overpricing