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10.1038/cddis.2014.205 http://scihub22266oqcxt.onion/10.1038/cddis.2014.205 C4047905!4047905 !24832604     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24832604 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24832604 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2014 ; 5 (5 ): e1232 Nephropedia Template TP {{tp|p=24832604 |t=2014. Understanding the roadmaps to induced pluripotency |pdf=|usr=}}{{24832604 }} gab.com Text Understanding the roadmaps to induced pluripotency JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=24832604 #FOAvip Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by ectopic expression of transcription factors Oct4, Sox2, Klf4 and cMyc. Recent advancements have shown that small-molecule compounds can induce pluripotency, indicating that cell fate can be regulated by direct manipulation of intrinsic cell signaling pathways, thereby innovating our current understanding of reprogramming. The fact that lineage specifiers can induce pluripotency suggests that the pluripotent state is a fine balance between competing differentiation forces. Dissection of pluripotent roadmaps indicates that reprogramming is a process of reverse development, involving a series of complicated and distinct reprogramming stages. Evidence from mouse iPSC transplantation studies demonstrated that some certain but not all cells derived from iPSCs are immunogenic. These studies provide new ways to minimize reprogramming-induced abnormalities and maximize reprogramming efficiency to facilitate clinical development and use of iPSCs. Twit Text FOAVip Understanding the roadmaps to induced pluripotency ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=24832604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24832604 #FOAvip English Wikipedia <ref>{{Cite pmid|24832604 }}</ref> Understanding the roadmaps to induced pluripotency #MMPMID24832604 Liu K ; Song Y ; Yu H ; Zhao T Cell Death Dis 2014[May]; 5 (5 ): e1232 PMID24832604 show ga Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by ectopic expression of transcription factors Oct4, Sox2, Klf4 and cMyc. Recent advancements have shown that small-molecule compounds can induce pluripotency, indicating that cell fate can be regulated by direct manipulation of intrinsic cell signaling pathways, thereby innovating our current understanding of reprogramming. The fact that lineage specifiers can induce pluripotency suggests that the pluripotent state is a fine balance between competing differentiation forces. Dissection of pluripotent roadmaps indicates that reprogramming is a process of reverse development, involving a series of complicated and distinct reprogramming stages. Evidence from mouse iPSC transplantation studies demonstrated that some certain but not all cells derived from iPSCs are immunogenic. These studies provide new ways to minimize reprogramming-induced abnormalities and maximize reprogramming efficiency to facilitate clinical development and use of iPSCs. |*Cell Differentiation/genetics [MESH] |*Cellular Reprogramming [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Cell Lineage [MESH] |Gene Expression Regulation, Developmental [MESH] |Humans [MESH] |Induced Pluripotent Stem Cells/immunology/*metabolism/transplantation [MESH] |Kruppel-Like Factor 4 [MESH] |Male [MESH] |Mice [MESH]Understanding the roadmaps to induced pluripotency (epmc).pdf DeepDyve Pubget Overpricing