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2015 ; 3
(3
): 133-40
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Understanding the biosynthesis of platelets-derived extracellular vesicles
#MMPMID26417432
Antwi-Baffour S
; Adjei J
; Aryeh C
; Kyeremeh R
; Kyei F
; Seidu MA
Immun Inflamm Dis
2015[Sep]; 3
(3
): 133-40
PMID26417432
show ga
Platelet-derived extracellular vesicles (PEVs) are described as sub-cellular
vesicles released into circulation upon platelets shear stress, activation,
injury, or apoptosis. They are considered as universal biomarkers in a wide range
of physiological and pathological processes. They are of tremendous significance
for the prediction, diagnosis, and observation of the therapeutic success of many
diseases. Understanding their biosynthesis and therefore functional properties
would contribute to a better understanding of the pathological mechanisms leading
to various diseases in which their levels are raised and they are implicated. The
review takes a critical look at the historical background of PEVs, their
structural components, the mechanism of their formation, physiological, and
exogenous stimuli inducing their release and their detection. It concludes by
highlighting on the importance of undertaking in-depth studies into PEVs
biosynthesis and subsequently gaining a better understanding of their biological
role in general.