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2016 ; 44
(6
): 447-50
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Understanding hematopoiesis from a single-cell standpoint
#MMPMID26997547
Kokkaliaris KD
; Lucas D
; Beerman I
; Kent DG
; Perié L
Exp Hematol
2016[Jun]; 44
(6
): 447-50
PMID26997547
show ga
The cellular diversity of the hematopoietic system has been extensively studied,
and a plethora of cell surface markers have been used to discriminate and
prospectively purify different blood cell types. However, even within
phenotypically identical fractions of hematopoietic stem and progenitor cells or
lineage-restricted progenitors, significant functional heterogeneity is observed
when single cells are analyzed. To address these challenges, researchers are now
using techniques to follow single cells and their progeny to improve our
understanding of the underlying functional heterogeneity. On November 19, 2015,
Dr. David Kent and Dr. Leïla Perié, two emerging young group leaders, presented
their recent efforts to dissect the functional properties of individual cells
with a webinar series organized by the International Society for Experimental
Hematology. Here, we provide a summary of the presented methods for cell labeling
and clonal tracking and discuss how these different techniques have been employed
to study hematopoiesis.
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