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Understanding essential tremor: progress on the biological front
#MMPMID24740806
Louis ED
Curr Neurol Neurosci Rep
2014[Jun]; 14
(6
): 450
PMID24740806
show ga
For many years, little was written about the underlying biology of ET, despite
its high prevalence. Discussions of disease mechanisms were dominated by a focus
on tremor physiology. The traditional model of ET, the olivary model, was
proposed in the 1970s. The model suffers from several critical problems, and its
relevance to ET has been questioned. Recent mechanistic research has focused on
the cerebellum. Clinical and neuroimaging studies strongly implicate the
importance of this brain region in ET. Recent mechanistic research has been
grounded more in tissue-based changes (i.e., postmortem studies of the brain).
These studies have collectively and systematically identified a sizable number of
changes in the ET cerebellum, and have led to a new model of ET, referred to as
the cerebellar degenerative model. Hence, there is a renewed interest in the
science behind the biology of ET. How the new understanding of ET will translate
into treatment changes is an open question.
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