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Understanding calcium waves and sparks in central neurons #MMPMID22314443
Ross WN
Nat Rev Neurosci 2012[Mar]; 13 (3): 157-68 PMID22314443show ga
All cells use changes in intracellular calcium concentration ([Ca2+]i) to regulate cell signalling events. In neurons, with their elaborate dendritic and axonal arborizations, there are clear examples of both localized and widespread Ca2+ signals. [Ca2+]i changes that are generated by Ca2+ entry through voltage- and ligand-gated channels are the best characterized. In addition, the release of Ca2+ from intracellular stores can result in increased [Ca2+]i; the signals that trigger this release have been less well-studied, in part because they are not usually associated with specific changes in membrane potential. However, recent experiments have revealed dramatic widespread Ca2+ waves and localized spark-like events, particularly in dendrites. Here we review emerging data on the nature of these signals and their functions.