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10.1016/j.str.2017.03.013

http://scihub22266oqcxt.onion/10.1016/j.str.2017.03.013
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C5530255!5530255 !28380338
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suck abstract from ncbi


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pmid28380338
      Structure 2017 ; 25 (4 ): 575-577
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  • Understanding CARD Tricks in Apoptosomes #MMPMID28380338
  • Wang L ; Qiao Q ; Wu H
  • Structure 2017[Apr]; 25 (4 ): 575-577 PMID28380338 show ga
  • While earlier studies of Apaf-1 holo-apoptosome architecture revealed the spectacular heptameric wheel-like structure formed by Apaf-1, the central CARD disk responsible for caspase-9 recruitment remained incompletely resolved. In a recent issue of Structure, Su et al. (2017) describe a crystal structure of the complex between Apaf-1 CARD and caspase-9 CARD. Together with two recent cryo-EM structures, this work brings us closer to a full view of the holo-apoptosome.
  • |Apoptosis [MESH]
  • |Apoptosomes/*chemistry [MESH]
  • |Apoptotic Protease-Activating Factor 1/chemistry [MESH]


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