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2017 ; 5
(ä): 36
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Uncovering the Roles of Septins in Cilia
#MMPMID28428954
Palander O
; El-Zeiry M
; Trimble WS
Front Cell Dev Biol
2017[]; 5
(ä): 36
PMID28428954
show ga
Septins are a family of GTP-binding proteins that associate with cellular
membranes and the cytoskeleton. Their ability to polymerize into filamentous
structures permits them to serve as diffusion barriers for membrane proteins and
as multi-molecular scaffolds that recruit components of signaling pathways. At
the cellular level, septins contribute to the regulation of numerous processes,
including cytokinesis, cell polarity, cell migration, and many others. In this
review, we discuss emerging evidence for roles of mammalian septins in the
biogenesis and function of flagella and cilia, and how this may impact human
diseases such as ciliopathies.