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2018 ; 10
(7
): 1705-1714
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Uncovering the Genomic Origins of Life
#MMPMID29947758
Lake JA
; Larsen J
; Tran DT
; Sinsheimer JS
Genome Biol Evol
2018[Jul]; 10
(7
): 1705-1714
PMID29947758
show ga
The Origin of Life Domain (OLD) is the period during which life on Earth began.
Here, we derive and use a new phylogenetic algorithm to analyze Protein Families
in order to reconstruct the chronological steps by which the OLD evolved. During
this period, life began with the appearance of the fundamental components of life
such as RNAs, DNAs, amino acids, and membranes. Chronologically, the Origin of
Life preceded the Last Universal Common Ancestor, which then subsequently
engendered modern life on Earth. Our phylogenetic algorithm allows us to
explicitly answer previously unknown origin of life questions. Specifically, we
explain and illustrate our computational methods by reconstructing the rings
describing the evolution of the RNA and DNA worlds. We phylogenetically
reconstruct how the RNA and DNA worlds evolved, infer the origins and
chronological order of appearance of the first genetic codes, test whether the
Ribosomal RNA world preceded the Membrane world, and interpret these new findings
with respect to the experimental and theoretical origin of life studies by
others.
free
free
free
