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2017 ; 92
(4
): 527-530
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Ultrastructural aspects of pseudoxanthoma elasticum
#MMPMID28954103
Almeida HL Jr
; Almeida MG
; Jorge VM
; Abreu LB
An Bras Dermatol
2017[Jul]; 92
(4
): 527-530
PMID28954103
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We report the ultrastructural findings in a case of a 72-year-old black woman
with confluent yellowish papules in the cervical region. She had no
comorbidities. Ophthalmological examination, electrocardiogram, and
echocardiogram were normal. Hematoxylin-eosin staining of the affected skin
showed strong alterations in the mid-dermis with irregular clumps of eosinophilic
material and loss of the normal parallel arrangement of collagen bundles. Orcein
staining revealed that the elastic fibers lost their normal linear configuration,
showing clump fragmentation, sometimes forming square structures. Transmission
electron microscopy showed aberrant elastic fibers with an irregular outline and
heterogenic inner structures. We also observed small elastic fibers. Collagen
fibers showed a normal structure with irregular distribution. Scanning electron
microscopy revealed important disorganization of collagen fibers and small
stone-like deposits measuring around 5 µm associated with bigger structures
ranging from 10-16 µm. Higher magnification revealed that these small stone-like
structures were sometimes polyhedral-shaped or squared.
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