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10.1016/j.celrep.2017.02.014 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.02.014 C5340982!5340982 !28249158     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28249158 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2017 ; 18 (9 ): 2113-2123 Nephropedia Template TP {{tp|p=28249158 |t=2017. Ultrastructural Characterization of Zika Virus Replication Factories |pdf=|usr=}}{{28249158 }} gab.com Text Ultrastructural Characterization of Zika Virus Replication Factories JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28249158 #FOAvip A global concern has emerged with the pandemic spread of Zika virus (ZIKV) infections that can cause severe neurological symptoms in adults and newborns. ZIKV is a positive-strand RNA virus replicating in virus-induced membranous replication factories (RFs). Here we used various imaging techniques to investigate the ultrastructural details of ZIKV RFs and their relationship with host cell organelles. Analyses of human hepatic cells and neural progenitor cells infected with ZIKV revealed endoplasmic reticulum (ER) membrane invaginations containing pore-like openings toward the cytosol, reminiscent to RFs in Dengue virus-infected cells. Both the MR766 African strain and the H/PF/2013 Asian strain, the latter linked to neurological diseases, induce RFs of similar architecture. Importantly, ZIKV infection causes a drastic reorganization of microtubules and intermediate filaments forming cage-like structures surrounding the viral RF. Consistently, ZIKV replication is suppressed by cytoskeleton-targeting drugs. Thus, ZIKV RFs are tightly linked to rearrangements of the host cell cytoskeleton. Twit Text FOAVip Ultrastructural Characterization of Zika Virus Replication Factories ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28249158 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28249158 #FOAvip English Wikipedia <ref>{{Cite pmid|28249158 }}</ref> Ultrastructural Characterization of Zika Virus Replication Factories #MMPMID28249158 Cortese M ; Goellner S ; Acosta EG ; Neufeldt CJ ; Oleksiuk O ; Lampe M ; Haselmann U ; Funaya C ; Schieber N ; Ronchi P ; Schorb M ; Pruunsild P ; Schwab Y ; Chatel-Chaix L ; Ruggieri A ; Bartenschlager R Cell Rep 2017[Feb]; 18 (9 ): 2113-2123 PMID28249158 show ga A global concern has emerged with the pandemic spread of Zika virus (ZIKV) infections that can cause severe neurological symptoms in adults and newborns. ZIKV is a positive-strand RNA virus replicating in virus-induced membranous replication factories (RFs). Here we used various imaging techniques to investigate the ultrastructural details of ZIKV RFs and their relationship with host cell organelles. Analyses of human hepatic cells and neural progenitor cells infected with ZIKV revealed endoplasmic reticulum (ER) membrane invaginations containing pore-like openings toward the cytosol, reminiscent to RFs in Dengue virus-infected cells. Both the MR766 African strain and the H/PF/2013 Asian strain, the latter linked to neurological diseases, induce RFs of similar architecture. Importantly, ZIKV infection causes a drastic reorganization of microtubules and intermediate filaments forming cage-like structures surrounding the viral RF. Consistently, ZIKV replication is suppressed by cytoskeleton-targeting drugs. Thus, ZIKV RFs are tightly linked to rearrangements of the host cell cytoskeleton. |Animals [MESH] |Cell Line [MESH] |Chlorocebus aethiops [MESH] |Endoplasmic Reticulum/ultrastructure/virology [MESH] |HEK293 Cells [MESH] |Hepatocytes/ultrastructure/virology [MESH] |Host-Pathogen Interactions/*physiology [MESH] |Humans [MESH] |Intermediate Filaments/metabolism/ultrastructure [MESH] |Microtubules/metabolism/ultrastructure [MESH] |Neural Stem Cells/ultrastructure/virology [MESH] |Stem Cells/ultrastructure/virology [MESH] |Vero Cells [MESH] |Virus Replication/*physiology [MESH] |Zika Virus Infection/metabolism/*virology [MESH]Ultrastructural Characterization of Zika Virus Replication Factories (epmc).pdf DeepDyve Pubget Overpricing