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10.1073/pnas.1604777113 http://scihub22266oqcxt.onion/10.1073/pnas.1604777113 C5056109!5056109 !27647910     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27647910 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (40 ): 11094-11099 Nephropedia Template TP {{tp|p=27647910 |t=2016. Ultradonut topology of the nuclear envelope |pdf=|usr=}}{{27647910 }} gab.com Text Ultradonut topology of the nuclear envelope JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27647910 #FOAvip The nuclear envelope is a unique topological structure formed by lipid membranes in eukaryotic cells. Unlike other membrane structures, the nuclear envelope comprises two concentric membrane shells fused at numerous sites with toroid-shaped pores that impart a "geometric" genus on the order of thousands. Despite the intriguing architecture and vital biological functions of the nuclear membranes, how they achieve and maintain such a unique arrangement remains unknown. Here, we used the theory of elasticity and differential geometry to analyze the equilibrium shape and stability of this structure. Our results show that modest in- and out-of-plane stresses present in the membranes not only can define the pore geometry, but also provide a mechanism for destabilizing membranes beyond a critical size and set the stage for the formation of new pores. Our results suggest a mechanism wherein nanoscale buckling instabilities can define the global topology of a nuclear envelope-like structure. Twit Text FOAVip Ultradonut topology of the nuclear envelope ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27647910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27647910 #FOAvip English Wikipedia <ref>{{Cite pmid|27647910 }}</ref> Ultradonut topology of the nuclear envelope #MMPMID27647910 Torbati M ; Lele TP ; Agrawal A Proc Natl Acad Sci U S A 2016[Oct]; 113 (40 ): 11094-11099 PMID27647910 show ga The nuclear envelope is a unique topological structure formed by lipid membranes in eukaryotic cells. Unlike other membrane structures, the nuclear envelope comprises two concentric membrane shells fused at numerous sites with toroid-shaped pores that impart a "geometric" genus on the order of thousands. Despite the intriguing architecture and vital biological functions of the nuclear membranes, how they achieve and maintain such a unique arrangement remains unknown. Here, we used the theory of elasticity and differential geometry to analyze the equilibrium shape and stability of this structure. Our results show that modest in- and out-of-plane stresses present in the membranes not only can define the pore geometry, but also provide a mechanism for destabilizing membranes beyond a critical size and set the stage for the formation of new pores. Our results suggest a mechanism wherein nanoscale buckling instabilities can define the global topology of a nuclear envelope-like structure. |*Models, Theoretical [MESH] |Cell Nucleus/chemistry/ultrastructure [MESH] |Elasticity [MESH] |Lipid Bilayers/*chemistry [MESH] |Nuclear Envelope/*chemistry/ultrastructure [MESH]Ultradonut topology of the nuclear envelope (epmc).pdf DeepDyve Pubget Overpricing