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10.18632/oncotarget.10948 http://scihub22266oqcxt.onion/10.18632/oncotarget.10948 C5325457!5325457!27486774     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27486774.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (39): 64471-504 Nephropedia Template TP {{tp|p=27486774|t=2016. Ubc13: the Lys63 ubiquitin chain building machine |pdf=|usr=}}{{27486774}} gab.com Text Ubc13: the Lys63 ubiquitin chain building machine JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27486774 #FOAvip Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory and DNA damage response pathways. Recent studies have suggested Ubc13 as a potential therapeutic target for intervention in various human diseases including several different cancers, alleviation of anti-cancer drug resistance, chronic inflammation, and viral infections. Understanding a potential therapeutic target from different angles is important to assess its usefulness and potential pitfalls. Here we present a global review of Ubc13 from its structure, function, and cellular activities, to its natural and chemical inhibition. The aim of this article is to review the literature that directly implicates Ubc13 in a biological function, and to integrate structural and mechanistic insights into the larger role of this critical E2 enzyme. We discuss observations of multiple Ubc13 structures that suggest a novel mechanism for activation of Ubc13 that involves conformational change of the active site loop. Twit Text FOAVip Ubc13: the Lys63 ubiquitin chain building machine ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27486774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27486774 #FOAvip English Wikipedia <ref>{{Cite pmid|27486774}}</ref> Ubc13: the Lys63 ubiquitin chain building machine #MMPMID27486774 Hodge CD; Spyracopoulos L; Glover JNM Oncotarget 2016[Sep]; 7 (39): 64471-504 PMID27486774show ga Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory and DNA damage response pathways. Recent studies have suggested Ubc13 as a potential therapeutic target for intervention in various human diseases including several different cancers, alleviation of anti-cancer drug resistance, chronic inflammation, and viral infections. Understanding a potential therapeutic target from different angles is important to assess its usefulness and potential pitfalls. Here we present a global review of Ubc13 from its structure, function, and cellular activities, to its natural and chemical inhibition. The aim of this article is to review the literature that directly implicates Ubc13 in a biological function, and to integrate structural and mechanistic insights into the larger role of this critical E2 enzyme. We discuss observations of multiple Ubc13 structures that suggest a novel mechanism for activation of Ubc13 that involves conformational change of the active site loop. äUbc13: the Lys63 ubiquitin chain building machine (epmc).pdf DeepDyve Pubget Overpricing