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10.1101/gad.301093.117 http://scihub22266oqcxt.onion/10.1101/gad.301093.117 C5695088!5695088 !29021241     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29021241 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2017 ; 31 (18 ): 1870-1879 Nephropedia Template TP {{tp|p=29021241 |t=2017. Two distinct transcription termination modes dictated by promoters |pdf=|usr=}}{{29021241 }} gab.com Text Two distinct transcription termination modes dictated by promoters JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=29021241 #FOAvip Transcription termination determines the ends of transcriptional units and thereby ensures the integrity of the transcriptome and faithful gene regulation. Studies in yeast and human cells have identified the exoribonuclease XRN2 as a key termination factor for protein-coding genes. Here we performed a genome-wide investigation of RNA polymerase II (Pol II) transcription termination in XRN2-deficient Caenorhabditis elegans and observed two distinct modes of termination. Although a subset of genes requires XRN2, termination of other genes appears both independent of, and refractory to, XRN2. XRN2 independence is not merely a consequence of failure to recruit XRN2, since XRN2 is present on-and promotes Pol II accumulation near the polyadenylation sites of-both gene classes. Unexpectedly, promoters instruct the choice of termination mode, but XRN2-independent termination additionally requires a compatible region downstream from the 3' end cleavage site. Hence, different termination mechanisms may work with different configurations of Pol II complexes dictated by promoters. Twit Text FOAVip Two distinct transcription termination modes dictated by promoters ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=29021241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29021241 #FOAvip English Wikipedia <ref>{{Cite pmid|29021241 }}</ref> Two distinct transcription termination modes dictated by promoters #MMPMID29021241 Miki TS ; Carl SH ; Großhans H Genes Dev 2017[Sep]; 31 (18 ): 1870-1879 PMID29021241 show ga Transcription termination determines the ends of transcriptional units and thereby ensures the integrity of the transcriptome and faithful gene regulation. Studies in yeast and human cells have identified the exoribonuclease XRN2 as a key termination factor for protein-coding genes. Here we performed a genome-wide investigation of RNA polymerase II (Pol II) transcription termination in XRN2-deficient Caenorhabditis elegans and observed two distinct modes of termination. Although a subset of genes requires XRN2, termination of other genes appears both independent of, and refractory to, XRN2. XRN2 independence is not merely a consequence of failure to recruit XRN2, since XRN2 is present on-and promotes Pol II accumulation near the polyadenylation sites of-both gene classes. Unexpectedly, promoters instruct the choice of termination mode, but XRN2-independent termination additionally requires a compatible region downstream from the 3' end cleavage site. Hence, different termination mechanisms may work with different configurations of Pol II complexes dictated by promoters. |*Promoter Regions, Genetic [MESH] |Animals [MESH] |Caenorhabditis elegans Proteins/genetics/*metabolism [MESH] |Caenorhabditis elegans/*genetics/metabolism [MESH] |Exoribonucleases/genetics/*metabolism [MESH] |RNA Interference [MESH] |RNA Polymerase II/genetics/*metabolism [MESH] |RNA, Messenger/genetics [MESH]Two distinct transcription termination modes dictated by promoters (epmc).pdf DeepDyve Pubget Overpricing