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10.1007/s13730-014-0145-y

http://scihub22266oqcxt.onion/10.1007/s13730-014-0145-y
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suck abstract from ncbi


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pmid28509277
      CEN+Case+Rep 2015 ; 4 (1 ): 85-89
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  • Two brothers with collagenofibrotic glomerulopathy #MMPMID28509277
  • Aoki T ; Hayashi K ; Morinaga T ; Tomida H ; Hishida M ; Yamamoto S ; Kajiwara N ; Tamai H
  • CEN Case Rep 2015[May]; 4 (1 ): 85-89 PMID28509277 show ga
  • Collagenofibrotic glomerulopathy is a rare glomerular disease characterized by extensive accumulation of atypical type III collagen fibers within the mesangial matrix and subendothelial space. Laboratory evaluation of this disease shows a marked increase in serum procollagen III peptide (P III P) levels. Here, we report the case of two brothers with collagenofibrotic glomerulopathy confirmed by histology. Patient 1 presented with proteinuria and hypertension and patient 2 presented with nephrotic-range proteinuria. Immunohistochemistry revealed strong staining for antibodies to type III collagen in the widened subendothelial spaces in both patients. Electron microscopy revealed numerous collagenous fibers in the mesangium and subendothelial space. P III P levels were elevated in both patients. Most reported cases of collagenofibrotic glomerulopathy, including the adult-onset type, have been sporadic. Within the limits of our literature search, this is only the third report of adult siblings with collagenofibrotic glomerulopathy confirmed by histology. This report indicates that it may be beneficial to measure serum P III P levels in the siblings of patients diagnosed with adult-onset collagenofibrotic glomerulopathy.
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