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2014 ; 8
(12
): 12041-8
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Turning erythrocytes into functional micromotors
#MMPMID25415461
Wu Z
; Li T
; Li J
; Gao W
; Xu T
; Christianson C
; Gao W
; Galarnyk M
; He Q
; Zhang L
; Wang J
ACS Nano
2014[Dec]; 8
(12
): 12041-8
PMID25415461
show ga
Attempts to apply artificial nano/micromotors for diverse biomedical applications
have inspired a variety of strategies for designing motors with diverse
propulsion mechanisms and functions. However, existing artificial motors are made
exclusively of synthetic materials, which are subject to serious immune attack
and clearance upon entering the bloodstream. Herein we report an elegant approach
that turns natural red blood cells (RBCs) into functional micromotors with the
aid of ultrasound propulsion and magnetic guidance. Iron oxide nanoparticles are
loaded into the RBCs, where their asymmetric distribution within the cells
results in a net magnetization, thus enabling magnetic alignment and guidance
under acoustic propulsion. The RBC motors display efficient guided and prolonged
propulsion in various biological fluids, including undiluted whole blood. The
stability and functionality of the RBC motors, as well as the tolerability of
regular RBCs to the ultrasound operation, are carefully examined. Since the RBC
motors preserve the biological and structural features of regular RBCs, these
motors possess a wide range of antigenic, transport, and mechanical properties
that common synthetic motors cannot achieve and thus hold considerable promise
for a number of practical biomedical uses.
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