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10.1080/23723556.2016.1240549

http://scihub22266oqcxt.onion/10.1080/23723556.2016.1240549
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suck abstract from ncbi


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pmid28090580
      Mol+Cell+Oncol 2016 ; 3 (6 ): e1240549
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  • Tumors smother their epigenome #MMPMID28090580
  • Thienpont B ; Van Dyck L ; Lambrechts D
  • Mol Cell Oncol 2016[]; 3 (6 ): e1240549 PMID28090580 show ga
  • DNA hypermethylation is pervasive in tumors, but the factors triggering this modification are largely unknown. We recently demonstrated that the activity of 10-11-translocation methylcytosine dioxygenases, initiators of DNA demethylation, is compromised in hypoxic tumors. The resultant accumulation of methylation inactivates associated genes, linking the tumor microenvironment to epigenetic changes in cancer cells.
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