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10.1016/j.yexcr.2017.01.013 http://scihub22266oqcxt.onion/10.1016/j.yexcr.2017.01.013 C5476446!5476446 !28132882     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28132882 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Cell+Res 2017 ; 352 (1 ): 20-33 Nephropedia Template TP {{tp|p=28132882 |t=2017. Tumor stroma interaction is mediated by monocarboxylate metabolism |pdf=|usr=}}{{28132882 }} gab.com Text Tumor stroma interaction is mediated by monocarboxylate metabolism JO: Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28132882 #FOAvip Human breast tumors contain significant amounts of stromal cells. There exists strong evidence that these stromal cells support cancer development and progression by altering various pathways (e.g. downregulation of tumor suppressor genes or autocrine signaling loops). Here, we suggest that stromal carcinoma-associated fibroblasts (CAFs), shown to be generated from bone marrow-derived mesenchymal stem cells, may (i) recycle tumor-derived lactate for their own energetic requirements, thereby sparing glucose for neighboring glycolytic tumor cells, and (ii) subsequently secrete surplus energetically and biosynthetically valuable metabolites of lactate oxidation, such as pyruvate, to support tumor growth. Lactate, taken up by stromal CAFs, is converted to pyruvate, which is then utilized by CAFs for energy needs as well as excreted and shared with tumor cells. We have interrogated lactate oxidation in CAFs to determine what metabolites may be secreted, and how they may affect the metabolism and growth of MDA-MB-231 breast cancer cells. We found that CAFs secrete pyruvate as a metabolite of lactate oxidation. Further, we show that pyruvate is converted to lactate to promote glycolysis in MDA-MB-231 cells and helps to control elevated ROS levels in these tumor cells. Finally, we found that inhibiting or interfering with ROS management, using the naturally occurring flavonoid phloretin (found in apple tree leaves), adds to the cytotoxicity of the conventional chemotherapeutic agent doxorubicin. Our work demonstrates that a lactate-pyruvate, reciprocally-supportive metabolic relationship may be operative within the tumor microenvironment (TME) to support tumor growth, and may be a useful drug target. Twit Text FOAVip Tumor stroma interaction is mediated by monocarboxylate metabolism ????Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28132882 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28132882 #FOAvip English Wikipedia <ref>{{Cite pmid|28132882 }}</ref> Tumor stroma interaction is mediated by monocarboxylate metabolism #MMPMID28132882 Patel BB ; Ackerstaff E ; Serganova IS ; Kerrigan JE ; Blasberg RG ; Koutcher JA ; Banerjee D Exp Cell Res 2017[Mar]; 352 (1 ): 20-33 PMID28132882 show ga Human breast tumors contain significant amounts of stromal cells. There exists strong evidence that these stromal cells support cancer development and progression by altering various pathways (e.g. downregulation of tumor suppressor genes or autocrine signaling loops). Here, we suggest that stromal carcinoma-associated fibroblasts (CAFs), shown to be generated from bone marrow-derived mesenchymal stem cells, may (i) recycle tumor-derived lactate for their own energetic requirements, thereby sparing glucose for neighboring glycolytic tumor cells, and (ii) subsequently secrete surplus energetically and biosynthetically valuable metabolites of lactate oxidation, such as pyruvate, to support tumor growth. Lactate, taken up by stromal CAFs, is converted to pyruvate, which is then utilized by CAFs for energy needs as well as excreted and shared with tumor cells. We have interrogated lactate oxidation in CAFs to determine what metabolites may be secreted, and how they may affect the metabolism and growth of MDA-MB-231 breast cancer cells. We found that CAFs secrete pyruvate as a metabolite of lactate oxidation. Further, we show that pyruvate is converted to lactate to promote glycolysis in MDA-MB-231 cells and helps to control elevated ROS levels in these tumor cells. Finally, we found that inhibiting or interfering with ROS management, using the naturally occurring flavonoid phloretin (found in apple tree leaves), adds to the cytotoxicity of the conventional chemotherapeutic agent doxorubicin. Our work demonstrates that a lactate-pyruvate, reciprocally-supportive metabolic relationship may be operative within the tumor microenvironment (TME) to support tumor growth, and may be a useful drug target. |*Tumor Microenvironment [MESH] |Autocrine Communication [MESH] |Breast Neoplasms/*metabolism/pathology [MESH] |Carbon Radioisotopes/metabolism [MESH] |Cell Communication [MESH] |Cells, Cultured [MESH] |Female [MESH] |Fibroblasts/*metabolism/pathology [MESH] |Glycolysis [MESH] |Humans [MESH] |Lactic Acid/*metabolism [MESH] |Metabolic Networks and Pathways [MESH] |Pyruvic Acid/*metabolism [MESH]Tumor stroma interaction is mediated by monocarboxylate metabolism (epmc).pdf DeepDyve Pubget Overpricing