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10.3390/biomedicines2020163 http://scihub22266oqcxt.onion/10.3390/biomedicines2020163 C5423468!5423468 !28548066     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28548066 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28548066 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomedicines 2014 ; 2 (2 ): 163-194 Nephropedia Template TP {{tp|p=28548066 |t=2014. Tumor Restrictions to Oncolytic Virus |pdf=|usr=}}{{28548066 }} gab.com Text Tumor Restrictions to Oncolytic Virus JO: Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=28548066 #FOAvip Oncolytic virotherapy has advanced since the days of its conception but therapeutic efficacy in the clinics does not seem to reach the same level as in animal models. One reason is premature oncolytic virus clearance in humans, which is a reasonable assumption considering the immune-stimulating nature of the oncolytic agents. However, several studies are beginning to reveal layers of restriction to oncolytic virotherapy that are present before an adaptive neutralizing immune response. Some of these barriers are present constitutively halting infection before it even begins, whereas others are raised by minute cues triggered by virus infection. Indeed, we and others have noticed that delivering viruses to tumors may not be the biggest obstacle to successful therapy, but instead the physical make-up of the tumor and its capacity to mount antiviral defenses seem to be the most important efficacy determinants. In this review, we summarize the constitutive and innate barriers to oncolytic virotherapy and discuss strategies to overcome them. Twit Text FOAVip Tumor Restrictions to Oncolytic Virus ????Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=28548066 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28548066 #FOAvip English Wikipedia <ref>{{Cite pmid|28548066 }}</ref> Tumor Restrictions to Oncolytic Virus #MMPMID28548066 Vähä-Koskela M ; Hinkkanen A Biomedicines 2014[Apr]; 2 (2 ): 163-194 PMID28548066 show ga Oncolytic virotherapy has advanced since the days of its conception but therapeutic efficacy in the clinics does not seem to reach the same level as in animal models. One reason is premature oncolytic virus clearance in humans, which is a reasonable assumption considering the immune-stimulating nature of the oncolytic agents. However, several studies are beginning to reveal layers of restriction to oncolytic virotherapy that are present before an adaptive neutralizing immune response. Some of these barriers are present constitutively halting infection before it even begins, whereas others are raised by minute cues triggered by virus infection. Indeed, we and others have noticed that delivering viruses to tumors may not be the biggest obstacle to successful therapy, but instead the physical make-up of the tumor and its capacity to mount antiviral defenses seem to be the most important efficacy determinants. In this review, we summarize the constitutive and innate barriers to oncolytic virotherapy and discuss strategies to overcome them. äTumor Restrictions to Oncolytic Virus (epmc).pdf DeepDyve Pubget Overpricing