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2018 ; 2018
(ä): 2852398
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Tubulointerstitial Biomarkers for Diabetic Nephropathy
#MMPMID29577044
Satirapoj B
J Diabetes Res
2018[]; 2018
(ä): 2852398
PMID29577044
show ga
Patients with diabetic nephropathy have a higher risk of mortality, mostly from
cardiovascular complications. Standard biomarkers including serum creatinine,
estimated glomerular filtration rate, and albuminuria are imprecise, do not
directly measure renal tissue injury, and are relatively insensitive to small
changes in renal function. Thus, availability of novel biomarkers that are
sensitive, specific, and precise as well as able to detect kidney injury and
predict clinically significant outcomes would be widely useful in diabetic
nephropathy. Novel biomarkers of the processes that induce tubulointerstitial
changes may ultimately prove to better predict renal progression and prognosis in
type 2 diabetes. Recently, certain biomarkers, which were initially identified in
acute kidney injury, also have been reported to confer value in evaluating
patients with chronic kidney disease. Biomarkers such as cystatin C, kidney
injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL),
angiotensinogen, periostin, and monocyte chemoattractant protein-1 (MCP-1)
reflect tubular injury. In this article, we focused on the potential applications
of these biomarkers in diabetic nephropathy.
|Angiotensinogen/blood
[MESH]
|Biomarkers/*blood
[MESH]
|Chemokine CCL2/blood
[MESH]
|Cystatin C/blood
[MESH]
|Diabetic Nephropathies/blood/*diagnosis
[MESH]
|Hepatitis A Virus Cellular Receptor 1/blood
[MESH]