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10.7554/eLife.16220 http://scihub22266oqcxt.onion/10.7554/eLife.16220 C5012864!5012864 !27472900     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27472900 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27472900 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27472900 |t=2016. Trisomy 21 consistently activates the interferon response |pdf=|usr=}}{{27472900 }} gab.com Text Trisomy 21 consistently activates the interferon response JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=27472900 #FOAvip Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis revealed that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoid cell lines, as well as circulating monocytes and T cells. Trisomy 21 cells show increased induction of interferon-stimulated genes and decreased expression of ribosomal proteins and translation factors. An shRNA screen determined that the interferon-activated kinases JAK1 and TYK2 suppress proliferation of trisomy 21 fibroblasts, and this defect is rescued by pharmacological JAK inhibition. Therefore, we propose that interferon activation, likely via increased gene dosage of the four interferon receptors encoded on chromosome 21, contributes to many of the clinical impacts of trisomy 21, and that interferon antagonists could have therapeutic benefits. Twit Text FOAVip Trisomy 21 consistently activates the interferon response ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=27472900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27472900 #FOAvip English Wikipedia <ref>{{Cite pmid|27472900 }}</ref> Trisomy 21 consistently activates the interferon response #MMPMID27472900 Sullivan KD ; Lewis HC ; Hill AA ; Pandey A ; Jackson LP ; Cabral JM ; Smith KP ; Liggett LA ; Gomez EB ; Galbraith MD ; DeGregori J ; Espinosa JM Elife 2016[Jul]; 5 (ä): ä PMID27472900 show ga Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis revealed that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoid cell lines, as well as circulating monocytes and T cells. Trisomy 21 cells show increased induction of interferon-stimulated genes and decreased expression of ribosomal proteins and translation factors. An shRNA screen determined that the interferon-activated kinases JAK1 and TYK2 suppress proliferation of trisomy 21 fibroblasts, and this defect is rescued by pharmacological JAK inhibition. Therefore, we propose that interferon activation, likely via increased gene dosage of the four interferon receptors encoded on chromosome 21, contributes to many of the clinical impacts of trisomy 21, and that interferon antagonists could have therapeutic benefits. |*Immunity, Innate [MESH] |Cells, Cultured [MESH] |Down Syndrome/*pathology [MESH] |Fibroblasts/*physiology [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Interferons/*metabolism [MESH] |Monocytes/immunology [MESH]Trisomy 21 consistently activates the interferon response (epmc).pdf DeepDyve Pubget Overpricing