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10.1177/1536012117714164 http://scihub22266oqcxt.onion/10.1177/1536012117714164 C5480627!5480627 !28627326     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28627326 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Imaging 2017 ; 16 (ä): 1536012117714164 Nephropedia Template TP {{tp|p=28627326 |t=2017. Triphenylamines Induce Cell Death Upon 2-Photon Excitation |pdf=|usr=}}{{28627326 }} gab.com Text Triphenylamines Induce Cell Death Upon 2-Photon Excitation JO: Mol Imaging http://www.kidney.de/pget.php?&tw=1&pmid=28627326 #FOAvip Photodynamic therapy (PDT) is a promising therapeutic method for several diseases, in particular for cancer. This approach uses a photosensitizer, oxygen, and an external light source to produce reactive oxygen species (ROS) at lethal doses to induce cell death. One drawback of current PDT is the use of visible light which has poor penetration in tissues. Such a limitation could be overcome by the use of novel organic compounds compatible with photoactivation under near-infrared light excitation. Triphenylamines (TPAs) are highly fluorescent compounds that are efficient to induce cell death upon visible light excitation (458 nm), but outside the biological spectral window. Interestingly, we recently showed that TPAs target cytoplasmic organelles of living cells, mainly mitochondria, and induce a high ROS production upon 2-photon excitation (in the 760-860 nm range), leading to a fast apoptosis process. However, we observed significant differences among the tested TPA compounds in terms of cell distribution and time courses of cell death-related events (apoptosis vs necrosis). In summary, TPAs represent serious candidates as photosensitizers that are compatible with 2-photon excitation to simultaneously trigger and imaging cell death although the relationship between their subcellular localization and the cell death mechanism involved is still a matter of debate. Twit Text FOAVip Triphenylamines Induce Cell Death Upon 2-Photon Excitation ????Mol Imaging http://www.kidney.de/pget.php?&tw=1&pmid=28627326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28627326 #FOAvip English Wikipedia <ref>{{Cite pmid|28627326 }}</ref> Triphenylamines Induce Cell Death Upon 2-Photon Excitation #MMPMID28627326 Chennoufi R ; Mahuteau-Betzer F ; Tauc P ; Teulade-Fichou MP ; Deprez E Mol Imaging 2017[Jan]; 16 (ä): 1536012117714164 PMID28627326 show ga Photodynamic therapy (PDT) is a promising therapeutic method for several diseases, in particular for cancer. This approach uses a photosensitizer, oxygen, and an external light source to produce reactive oxygen species (ROS) at lethal doses to induce cell death. One drawback of current PDT is the use of visible light which has poor penetration in tissues. Such a limitation could be overcome by the use of novel organic compounds compatible with photoactivation under near-infrared light excitation. Triphenylamines (TPAs) are highly fluorescent compounds that are efficient to induce cell death upon visible light excitation (458 nm), but outside the biological spectral window. Interestingly, we recently showed that TPAs target cytoplasmic organelles of living cells, mainly mitochondria, and induce a high ROS production upon 2-photon excitation (in the 760-860 nm range), leading to a fast apoptosis process. However, we observed significant differences among the tested TPA compounds in terms of cell distribution and time courses of cell death-related events (apoptosis vs necrosis). In summary, TPAs represent serious candidates as photosensitizers that are compatible with 2-photon excitation to simultaneously trigger and imaging cell death although the relationship between their subcellular localization and the cell death mechanism involved is still a matter of debate. |Apoptosis/physiology [MESH] |Cell Death/physiology [MESH] |Humans [MESH] |Optical Imaging/methods [MESH] |Photochemotherapy/*methods [MESH] |Photosensitizing Agents/*chemistry [MESH]Triphenylamines Induce Cell Death Upon 2-Photon Excitation (epmc).pdf DeepDyve Pubget Overpricing