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2016 ; 7
(2
): e00553-16
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Trimming Surface Sugars Protects Histoplasma from Immune Attack
#MMPMID27118584
Brown GD
mBio
2016[Apr]; 7
(2
): e00553-16
PMID27118584
show ga
Dectin-1 is an essential innate immune receptor that recognizes ?-glucans in
fungal cell walls. Its importance is underscored by the mechanisms that fungal
pathogens have evolved to avoid detection by this receptor. One such pathogen is
Histoplasma capsulatum, and in a recent article in mBio, Rappleye's group
presented data showing that yeasts of this organism secrete a ?-glucanase, Eng1,
which acts to prune ?-glucans that are exposed on the fungal cell surface [A. L.
Garfoot et al., mBio 7(2):e01388-15, 2016,
http://dx.doi.org/10.1128/mBio.01388-15]. The trimming of these sugars reduces
immune recognition through Dectin-1 and subsequent inflammatory responses,
enhancing the pathogenesis of H. capsulatum.