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2008 ; 1
(2
): 18
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Trigger Versus Substrate Ablation for Atrial Fibrillation
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Verma A
J Atr Fibrillation
2008[Jul]; 1
(2
): 18
PMID28496577
show ga
Elimination of triggers has become the hallmark of catheter ablation of atrial
fibrillation (AF). In particular, much attention has been paid to the elimination
of triggering impulses from the pulmonary veins via pulmonary vein ablation
procedures. While this approach has a proven track record for paroxysmal AF, the
efficacy in non-paroxysmal AF has been less convincing. Thus, attention has been
paid to elimination of the substrate responsible for AF perpetuation, including
complex fractionated electrograms, dominant frequency sites, and autonomic
ganglionated plexi. None of these targets has yet become mainstream, but they are
all under active investigation. As our knowledge of these targets increases and
clinical studies are performed, a more refined approach to AF ablation will
surely emerge.