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10.1042/BST20150117 http://scihub22266oqcxt.onion/10.1042/BST20150117 C4613494!4613494 !26517933     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26517933 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26517933 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochem+Soc+Trans 2015 ; 43 (5 ): 1112-5 Nephropedia Template TP {{tp|p=26517933 |t=2015. Tribbles in normal and malignant haematopoiesis |pdf=|usr=}}{{26517933 }} gab.com Text Tribbles in normal and malignant haematopoiesis JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=26517933 #FOAvip The tribbles protein family, an evolutionarily conserved group of pseudokinases, have been shown to regulate multiple cellular events including those involved in normal and malignant haematopoiesis. The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ligase-binding domain. In this review, we focus on the role of Trib (mammalian Tribbles homologues) proteins in mammalian haematopoiesis and leukaemia. The Trib proteins show divergent expression in haematopoietic cells, probably indicating cell-specific functions. The roles of the Trib proteins in oncogenesis are also varied and appear to be tissue-specific. Finally, we discuss the potential mechanisms by which the Trib proteins preferentially regulate these processes in multiple cell types. Twit Text FOAVip Tribbles in normal and malignant haematopoiesis ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=26517933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26517933 #FOAvip English Wikipedia <ref>{{Cite pmid|26517933 }}</ref> Tribbles in normal and malignant haematopoiesis #MMPMID26517933 Stein SJ ; Mack EA ; Rome KS ; Pear WS Biochem Soc Trans 2015[Oct]; 43 (5 ): 1112-5 PMID26517933 show ga The tribbles protein family, an evolutionarily conserved group of pseudokinases, have been shown to regulate multiple cellular events including those involved in normal and malignant haematopoiesis. The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ligase-binding domain. In this review, we focus on the role of Trib (mammalian Tribbles homologues) proteins in mammalian haematopoiesis and leukaemia. The Trib proteins show divergent expression in haematopoietic cells, probably indicating cell-specific functions. The roles of the Trib proteins in oncogenesis are also varied and appear to be tissue-specific. Finally, we discuss the potential mechanisms by which the Trib proteins preferentially regulate these processes in multiple cell types. |Acute Disease [MESH] |Animals [MESH] |Calcium-Calmodulin-Dependent Protein Kinases/*genetics [MESH] |Gene Expression Regulation, Leukemic [MESH] |Hematopoiesis/*genetics [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/*genetics [MESH] |Leukemia, Myeloid/*genetics [MESH] |Models, Genetic [MESH] |Protein Serine-Threonine Kinases/*antagonists & inhibitors/genetics [MESH]Tribbles in normal and malignant haematopoiesis (epmc).pdf DeepDyve Pubget Overpricing