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10.4161/21624011.2014.957994 http://scihub22266oqcxt.onion/10.4161/21624011.2014.957994 C4292223!4292223 !25941578     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25941578 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncoimmunology 2014 ; 3 (10 ): e957994 Nephropedia Template TP {{tp|p=25941578 |t=2014. Trial watch: IDO inhibitors in cancer therapy |pdf=|usr=}}{{25941578 }} gab.com Text Trial watch: IDO inhibitors in cancer therapy JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=25941578 #FOAvip Indoleamine 2,3-dioxigenase 1 (IDO1) is the main enzyme that catalyzes the first, rate-limiting step of the so-called "kynurenine pathway", i.e., the metabolic cascade that converts the essential amino acid L-tryptophan (Trp) into L-kynurenine (Kyn). IDO1, which is expressed constitutively by some tissues and in an inducible manner by specific subsets of antigen-presenting cells, has been shown to play a role in the establishment and maintenance of peripheral tolerance. At least in part, this reflects the capacity of IDO1 to restrict the microenvironmental availability of Trp and to favor the accumulation of Kyn and some of its derivatives. Also, several neoplastic lesions express IDO1, providing them with a means to evade anticancer immunosurveillance. This consideration has driven the development of several IDO1 inhibitors, some of which (including 1-methyltryptophan) have nowadays entered clinical evaluation. In animal tumor models, the inhibition of IDO1 by chemical or genetic interventions is indeed associated with the (re)activation of therapeutically relevant anticancer immune responses. This said, several immunotherapeutic regimens exert robust clinical activity in spite of their ability to promote the expression of IDO1. Moreover, 1-methyltryptophan has recently been shown to exert IDO1-independent immunostimulatory effects. Here, we summarize the preclinical and clinical studies testing the antineoplastic activity of IDO1-targeting interventions. Twit Text FOAVip Trial watch: IDO inhibitors in cancer therapy ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=25941578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25941578 #FOAvip English Wikipedia <ref>{{Cite pmid|25941578 }}</ref> Trial watch: IDO inhibitors in cancer therapy #MMPMID25941578 Vacchelli E ; Aranda F ; Eggermont A ; Sautès-Fridman C ; Tartour E ; Kennedy EP ; Platten M ; Zitvogel L ; Kroemer G ; Galluzzi L Oncoimmunology 2014[Nov]; 3 (10 ): e957994 PMID25941578 show ga Indoleamine 2,3-dioxigenase 1 (IDO1) is the main enzyme that catalyzes the first, rate-limiting step of the so-called "kynurenine pathway", i.e., the metabolic cascade that converts the essential amino acid L-tryptophan (Trp) into L-kynurenine (Kyn). IDO1, which is expressed constitutively by some tissues and in an inducible manner by specific subsets of antigen-presenting cells, has been shown to play a role in the establishment and maintenance of peripheral tolerance. At least in part, this reflects the capacity of IDO1 to restrict the microenvironmental availability of Trp and to favor the accumulation of Kyn and some of its derivatives. Also, several neoplastic lesions express IDO1, providing them with a means to evade anticancer immunosurveillance. This consideration has driven the development of several IDO1 inhibitors, some of which (including 1-methyltryptophan) have nowadays entered clinical evaluation. In animal tumor models, the inhibition of IDO1 by chemical or genetic interventions is indeed associated with the (re)activation of therapeutically relevant anticancer immune responses. This said, several immunotherapeutic regimens exert robust clinical activity in spite of their ability to promote the expression of IDO1. Moreover, 1-methyltryptophan has recently been shown to exert IDO1-independent immunostimulatory effects. Here, we summarize the preclinical and clinical studies testing the antineoplastic activity of IDO1-targeting interventions. äTrial watch: IDO inhibitors in cancer therapy (epmc).pdf DeepDyve Pubget Overpricing