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2017 ; 73
(Pt 6
): 503-508
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Trends in the Electron Microscopy Data Bank (EMDB)
#MMPMID28580912
Patwardhan A
Acta Crystallogr D Struct Biol
2017[Jun]; 73
(Pt 6
): 503-508
PMID28580912
show ga
Recent technological advances, such as the introduction of the direct electron
detector, have transformed the field of cryo-EM and the landscape of molecular
and cellular structural biology. This study analyses these trends from the
vantage point of the Electron Microscopy Data Bank (EMDB), the public archive for
three-dimensional EM reconstructions. Over 1000 entries were released in 2016,
representing almost a quarter of the total number of entries (4431). Structures
at better than 6?Å resolution now represent one of the fastest-growing
categories, while the share of annually released tomography-related structures is
approaching 20%. The use of direct electron detectors is growing very rapidly:
they were used for 70% of the structures released in 2016, in contrast to none
before 2011. Microscopes from FEI have an overwhelming lead in terms of usage,
and the use of the RELION software package continues to grow rapidly after having
attained a leading position in the field. China is rapidly emerging as a major
player in the field, supplementing the US, Germany and the UK as the big four.
Similarly, Tsinghua University ranks only second to the MRC Laboratory for
Molecular Biology in terms of involvement in publications associated with cryo-EM
structures at better than 4?Å resolution. Overall, the numbers point to a rapid
democratization of the field, with more countries and institutes becoming
involved.