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2014 ; 5
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Treatment principles for Candida and Cryptococcus
#MMPMID25384767
Whitney LC
; Bicanic T
Cold Spring Harb Perspect Med
2014[Nov]; 5
(6
): ä PMID25384767
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The yeasts Candida and Cryptococcus spp. are important human opportunistic
pathogens. Candida spp. rely on skin or mucosal breach to cause bloodstream
infection, whereas Cryptococcus spp. exploit depressed cell-mediated immunity
characteristic of advanced HIV infection. The treatment for both organisms relies
on the administration of rapidly fungicidal agents. In candidaemia, source
control is important, with removal of prosthetic material and drainage of
collections, as well as hunting for and tailoring therapy to disseminated sites
of infection, particularly the eyes and heart. For cryptococcal meningitis,
restoration of immune function through antiretroviral therapy (ART) is key,
together with careful management of the complications of raised intracranial
pressure and relapsed infection, both pre- and post-ART.
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