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2015 ; 4
(ä): 755
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Treatment of bone marrow lesions (bone marrow edema)
#MMPMID26644910
Eriksen EF
Bonekey Rep
2015[]; 4
(ä): 755
PMID26644910
show ga
Bone marrow lesions (BMLs) or using older terminology 'Bone marrow edema' is
characterised by excessive water signals in the marrow space on magnetic
resonance imaging or ultrasound; BMLs constitute a central component of a wide
variety of inflammatory and non-inflammatory rheumatologic conditions affecting
the musculoskeletal system: BMLs are not only considered significant sources of
pain but also linked to increased disease activity in many musculoskeletal
conditions (for example, osteoarthritis, rheumatoid arthritis). The purpose of
this review is to summarise current knowledge about the treatment of BMLs, with
an emphasis on the clinical and histological features of this entity in
inflammatory and non-inflammatory disease. We also try to pair this hypothesis
with the apparent beneficial effects of various treatment regimens, mainly within
the group of bone antiresorptive drugs (calcitonin, bisphosphonates) on symptoms
associated with BMLs.