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2006 ; 2
(3
): 203-208
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Treatment of Recurrent Clostridium difficile Diarrhea
#MMPMID28286449
Huebner ES
; Surawicz CM
Gastroenterol Hepatol (N Y)
2006[Mar]; 2
(3
): 203-208
PMID28286449
show ga
Treatment of recurrent Clostridium difficile-associated diarrhea can be
challenging. Once patients develop recurrent disease, further episodes are common
and can continue for months or even a year or more. Treatment begins with a
repeat standard 10-day course of antibiotics, followed by tapering and/or pulsing
of the antibiotic dose. Probiotics can also be useful, particularly the
nonpathogenic yeast Saccharomyces boulardii. Stool reconstitution via fecal
enemas, colonoscopy, and nasogastric tubes have been performed to restore normal
colonic flora. Additional approaches under investigation, such as vaccination
against C. difficile, show encouraging preliminary results.