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2015 ; 2015
(ä): 984570
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Treatment of Cancer Pain by Targeting Cytokines
#MMPMID26538839
Vendrell I
; Macedo D
; Alho I
; Dionísio MR
; Costa L
Mediators Inflamm
2015[]; 2015
(ä): 984570
PMID26538839
show ga
Inflammation is one of the most important causes of the majority of cancer
symptoms, including pain, fatigue, cachexia, and anorexia. Cancer pain affects 17
million people worldwide and can be caused by different mediators which act in
primary efferent neurons directly or indirectly. Cytokines can be aberrantly
produced by cancer and immune system cells and are of particular relevance in
pain. Currently, there are very few strategies to control the release of
cytokines that seems to be related to cancer pain. Nevertheless, in some cases,
targeted drugs are available and in use for other diseases. In this paper, we aim
to review the importance of cytokines in cancer pain and targeted strategies that
can have an impact on controlling this symptom.
|Adrenal Cortex Hormones/metabolism
[MESH]
|Analgesics, Opioid/metabolism
[MESH]
|Animals
[MESH]
|Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
[MESH]
|Chemokines/metabolism
[MESH]
|Cyclooxygenase 2/metabolism
[MESH]
|Cytokines/*metabolism
[MESH]
|Endothelin-1/metabolism
[MESH]
|Humans
[MESH]
|Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
[MESH]
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