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10.3238/arztebl.2017.0011 http://scihub22266oqcxt.onion/10.3238/arztebl.2017.0011 C5373481!5373481!28143635     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28143635&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28143635.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Dtsch+Arztebl+Int 2017 ; 114 (1-2): 11-21 Nephropedia Template TP {{tp|p=28143635|t=2017. Treatment Options in Hepatitis C: The Current State of the Art |pdf=|usr=}}{{28143635}} gab.com Text Treatment Options in Hepatitis C: The Current State of the Art JO: Dtsch Arztebl Int http://www.kidney.de/pget.php?&tw=1&pmid=28143635 #FOAvip Background: Among patients with chronic hepatitis C, 20?30% develop hepatic cirrhosis and its complications within 30 years. The antiviral treatment of hepatitis C, previously interferon-based, has recently become interferon-free, with resulting improvements in sustained virological response rates, safety, and tolerability and a shorter duration of treatment. Methods: This review is based on relevant publications retrieved by a selective literature search, and particularly on studies and reviews concerning the course and treatment of hepatitis C. Results: The available drugs for interferon-free antiviral treatment of hepatitis C include inhibitors of the RNA-dependent RNA polymerase, NS3/4A protease, and NS5A protein of the hepatitis C virus (HCV), and ribavirin. Typically, two specific inhibitors are given in combination; the usual duration of treatment is 12 weeks.The antiviral drugs differ in their genotypic antiviral effectiveness and resistance barriers. The appropriate drug(s) should be chosen in consideration of the patient?s hepatic and renal function and potential drug interactions. These drugs are safe and well-tolerated and result in sustained virological response rates between 90% and 100%. Conclusion: All patients with hepatitis C, whatever their disease stage, can derive a sustained eradication of HCV from a combination of drugs with direct antiviral activity. Viral eradication is associated with a better quality of life and with lower morbidity and mortality. Twit Text FOAVip Treatment Options in Hepatitis C: The Current State of the Art ????Dtsch Arztebl Int http://www.kidney.de/pget.php?&tw=1&pmid=28143635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28143635 #FOAvip English Wikipedia <ref>{{Cite pmid|28143635}}</ref> Treatment Options in Hepatitis C: The Current State of the Art #MMPMID28143635 Zeuzem S Dtsch Arztebl Int 2017[Jan]; 114 (1-2): 11-21 PMID28143635show ga Background: Among patients with chronic hepatitis C, 20?30% develop hepatic cirrhosis and its complications within 30 years. The antiviral treatment of hepatitis C, previously interferon-based, has recently become interferon-free, with resulting improvements in sustained virological response rates, safety, and tolerability and a shorter duration of treatment. Methods: This review is based on relevant publications retrieved by a selective literature search, and particularly on studies and reviews concerning the course and treatment of hepatitis C. Results: The available drugs for interferon-free antiviral treatment of hepatitis C include inhibitors of the RNA-dependent RNA polymerase, NS3/4A protease, and NS5A protein of the hepatitis C virus (HCV), and ribavirin. Typically, two specific inhibitors are given in combination; the usual duration of treatment is 12 weeks.The antiviral drugs differ in their genotypic antiviral effectiveness and resistance barriers. The appropriate drug(s) should be chosen in consideration of the patient?s hepatic and renal function and potential drug interactions. These drugs are safe and well-tolerated and result in sustained virological response rates between 90% and 100%. Conclusion: All patients with hepatitis C, whatever their disease stage, can derive a sustained eradication of HCV from a combination of drugs with direct antiviral activity. Viral eradication is associated with a better quality of life and with lower morbidity and mortality. äTreatment Options in Hepatitis C: The Current State of the Art (epmc).pdf DeepDyve Pubget Overpricing