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2017 ; 292
(20
): 8122-8135
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Traversing the RNA world
#MMPMID28381442
Filipowicz W
J Biol Chem
2017[May]; 292
(20
): 8122-8135
PMID28381442
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An invitation to write a "Reflections" type of article creates a certain
ambivalence: it is a great honor, but it also infers the end of your professional
career. Before you vanish for good, your colleagues look forward to an
interesting but entertaining account of the ups-and-downs of your past research
and your views on science in general, peppered with indiscrete anecdotes about
your former competitors and collaborators. What follows will disappoint those who
await complaint and criticism, for example, about the difficulties of doing
research in the 1960s and 1970s in Eastern Europe, or those seeking very personal
revelations. My scientific life has in fact seen many happy coincidences, much
good fortune, and several lucky escapes from situations that at the time were
quite scary. I have also been fortunate with regard to competitors and
collaborators, particularly because, whenever possible, I tried to "neutralize"
my rivals by collaborating with them - to the benefit of all. I recommend this
strategy to young researchers to dispel the nightmares that can occur when
competing against powerful contenders. I have been blessed with the selection of
my research topic: RNA biology. Over the last five decades, new and unexpected
RNA-related phenomena emerged almost yearly. I experienced them very personally
while studying transcription, translation, RNA splicing, ribosome biogenesis, and
more recently, different classes of regulatory non-coding RNAs, including
microRNAs. Some selected research and para-research stories, also covering many
wonderful people I had a privilege to work with, are summarized below.
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