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2018 ; 46
(6
): 2170-2176
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Traumatic glioblastoma: commentary and suggested mechanism
#MMPMID29708004
Ohana N
; Benharroch D
; Sheinis D
; Cohen A
J Int Med Res
2018[Jun]; 46
(6
): 2170-2176
PMID29708004
show ga
The role of head trauma in the development of glioblastoma is highly
controversial and has been minimized since first put forward. This is not
unexpected because skull injuries are overwhelmingly more common than
glioblastoma. This paper presents a commentary based on the contributions of
James Ewing, who established a major set of criteria for the recognition of an
official relationship between trauma and cancer. Ewing's criteria were very
stringent. The scholars who succeeded Ewing have facilitated the characterization
of traumatic brain injuries since the introduction of computed tomography and
magnetic resonance imaging. Discussions of the various criteria that have since
developed are now being conducted, and those of an unnecessarily limiting nature
are being highlighted. Three transcription factors associated with traumatic
brain injury have been identified: p53, hypoxia-inducible factor-1?, and c-MYC. A
role for these three transcription factors in the relationship between traumatic
brain injury and glioblastoma is suggested; this role may support a
cause-and-effect link with the subsequent development of glioblastoma.
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