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2016 ; 147
(3
): 267-8
Nephropedia Template TP
Immunology
2016[Mar]; 147
(3
): 267-8
PMID26694700
show ga
The concept of immunological tolerance--the state of specific unresponsiveness to
allogeneic transplants and all manner of other antigens--began in 1945 with R.D.
Owen's finding that cattle dizygotic twins are red blood cell chimeras. Peter
Medawar's group in Birmingham likewise discovered, quite independently, that
cattle dizygotic twins accept each others' skin grafts. These findings, together
with F.M. Burnet and F. Fenner's speculations in 1949, prompted Medawar, together
with R.E. Billingham and L. Brent, now at University College London, to embark on
an extensive series of experiments that established immunological tolerance as a
fundamental phenomenon, forming a new branch of immunology.
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