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2017 ; 15
(9
): 531-543
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Transmission of the gut microbiota: spreading of health
#MMPMID28603278
Browne HP
; Neville BA
; Forster SC
; Lawley TD
Nat Rev Microbiol
2017[Sep]; 15
(9
): 531-543
PMID28603278
show ga
Transmission of commensal intestinal bacteria between humans could promote health
by establishing, maintaining and replenishing microbial diversity in the
microbiota of an individual. Unlike pathogens, the routes of transmission for
commensal bacteria remain unappreciated and poorly understood, despite the likely
commonalities between both. Consequently, broad infection control measures that
are designed to prevent pathogen transmission and infection, such as
oversanitation and the overuse of antibiotics, may inadvertently affect human
health by altering normal commensal transmission. In this Review, we discuss the
mechanisms and factors that influence host-to-host transmission of the intestinal
microbiota and examine how a better understanding of these processes will
identify new approaches to nurture and restore transmission routes that are used
by beneficial bacteria.